Detaillierte Hinweise zur Behandlung von Opioidsucht

Detaillierte Hinweise zur Behandlung von Opioidsucht

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Methadone hydrochloride tablets can cause life-threatening heartbeat problems that can lead to death. Most heartbeat problems have happened in people using large doses of methadone hydrochloride tablets for pain treatment.

Regardless of the dose determination strategy employed, methadone is most safely initiated and titrated using small initial doses and gradual dose adjustments.

Call your doctor right away if you have serious side effects. Call 911 if your symptoms feel life threatening or if you think you’re having a medical emergency. Serious side effects and their symptoms can include the following:

Zidovudine – Experimental evidence demonstrated that methadone increased the area under the concentration-time curve (AUC) of zidovudine which could result rein toxic effects.

Particular vigilance is necessary during treatment initiation, during conversion from one opioid to another, and during dose titration.

Dispose of any unused methadone hydrochloride tablets remaining from a prescription as soon as they are no longer needed. Unused tablets should be flushed down the toilet.

Side effects from methadone: Taking methadone with certain medications raises your risk of side effects from methadone. This is because the amount of methadone in your body is increased. Examples of these drugs include:

Methadone differs from many other opioid agonists rein several important ways. Methadone's pharmacokinetic properties, coupled with high interpatient variability hinein its absorption, metabolism, and relative analgesic potency, necessitate a cautious and highly individualized approach to prescribing. Particular vigilance is necessary during treatment initiation, during conversion from one opioid to another, and during dose titration. While methadone's duration of analgesic action (typically 4 to 8 hours) hinein the Rahmen of single-dose studies approximates that of morphine, methadone's plasma elimination half-life is substantially longer than that of morphine (typically 8 to 59 hours vs.

Extreme caution is necessary when any drug known to have the potential to prolong the QT interval is prescribed in conjunction with methadone.

“Doctor shopping” (visiting multiple prescribers) to obtain additional prescriptions is common among drug abusers and people suffering from untreated addiction. However, it should Beryllium important to Schulnote that preoccupation with achieving adequate pain relief can Beryllium appropriate behavior rein a patient with poor pain control.

Antibiotics, such as clarithromycin and erythromycin. Taking these drugs with methadone may cause increased drowsiness and slowed breathing. Your doctor might adjust your dosage of methadone, depending on how severe your side effects are.

Cimetidine. Taking this drug with methadone may cause increased drowsiness and slowed breathing. Your doctor might adjust your dosage of methadone, depending on how severe your side effects are.

Desipramine – Blood levels of desipramine have increased with concurrent methadone administration.

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